Russian Journal of Pediatric SurgeryRussian Journal of Pediatric SurgeryДетская хирургия1560-95102412-0677Eco-Vector79510.17816/ps795ReviewsНаучные обзорыReview ArticleBiomarkers of renal parenchymal damage in young children with congenital hydronephrosis: literature reviewБиомаркеры повреждения почечной паренхимы у детей раннего возраста c врождённым гидронефрозом: обзор литературыhttps://orcid.org/0000-0002-1556-60109696-4736KlimovVladislav N.КлимовВладислав Николаевич
Russian Federation
klimov.surg@mail.ruhttps://orcid.org/0000-0001-5525-86488583-6925DeryuginaLyudmila A.ДерюгинаЛюдмила Александровна
Russian Federation

MD, Dr. Sci. (Medicine), Professor

д-р мед. наук, проф.

dludmila1@yandex.ruhttps://orcid.org/0000-0003-1060-95175483-0762KrasnovaElena I.КрасноваЕлена Ивановна
Russian Federation

MD, Cand. Sci. (Medicine), Assoc. Professor

канд. мед. наук, доц.

krasnovasaratov@yandex.ruhttps://orcid.org/0000-0002-7662-47557810-3930PopyhovaEra B.ПопыховаЭра Борисовна
Russian Federation

Cand. Sci. (Biology)

канд. биол. наук

popyhovaeb@mail.ruhttps://orcid.org/0009-0006-9835-0149KazymovDzhalal F.КазымовДжалал Фарман оглы
Russian Federation
k.jalal@mail.ruSaratov State Medical University named after V.I. RazumovskyСаратовский государственный медицинский университет имени В.И. Разумовского19102024111120242854824930203202423092024Copyright ©; 2024, Klimov V.N., Deryugina L.A., Krasnova E.I., Popyhova E.B., Kazymov D.F.Copyright ©; 2024, Климов В.Н., Дерюгина Л.А., Краснова Е.И., Попыхова Э.Б., Казымов Д.Ф.2024Klimov V.N., Deryugina L.A., Krasnova E.I., Popyhova E.B., Kazymov D.F.Климов В.Н., Дерюгина Л.А., Краснова Е.И., Попыхова Э.Б., Казымов Д.Ф.https://eco-vector.com/for_authors.php#07https://jps-nmp.ru/jour/article/view/795

Enlargement of the renal cavity system in a fetus is revealed at prenatal ultrasound in 1–5% of cases and can be caused by congenital hydronephrosis due to pelvic-ureteral junction obstruction, which is one of the most common nosologies in the structure of obstructive uropathies in childhood. A high risk of renal function decrease at the preclinical stage of disease development dictates a need to create highly informative diagnostic programs and treatment algorithms aimed at preventing complications. In this review, we discuss results of studies on diagnostic and prognostic value of cytokine biomarkers which are of a great interest in congenital hydronephrosis in young children. They include: kidney injury molecule-1, vascular endothelial growth factor-A, monocyte chemoattractant protein-1, neutrophil gelatinase-associated lipocalin, interleukin-1. Literature search for this review was made in Web of Science, PubMed, Russian Science Citation Index, CyberLeninka, Scopus databases.

Расширение полостной системы почек плода встречается в ходе пренатального ультразвукового исследования в 1–5% случаев выявления дилятации верхних мочевых путей у плодов в пренатальном периоде и может быть обусловлено врождённым гидронефрозом вследствие стеноза пиелоуретерального сегмента мочеточника, что является одной из наиболее часто встречающихся нозологий в структуре обструктивных уропатий в детском возрасте. Высокий риск снижения почечных функций на доклиническом этапе развития заболевания диктует необходимость создания высокоинформативных диагностических программ и лечебных алгоритмов, направленных на предотвращение развития осложнений. В настоящем обзоре мы обсуждаем результаты исследований диагностической и прогностической ценности биомаркеров цитокинового ряда, представляющих наибольший интерес при врождённом гидронефрозе у детей раннего возраста, к ним относятся: молекула повреждения почек-1, фактор роста эндотелия сосудов-А, моноцитарный хемоаттрактантный белок-1, липокалин, ассоциированный с желатиназой нейтрофилов, интерлейкин-1. Поиск литературы при написании настоящего обзора осуществляли по базам данных Web of Science, PubMed, Российский индекс научного цитирования, КиберЛенинка, Scopus.

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