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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Pediatric Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Pediatric Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Детская хирургия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1560-9510</issn><issn publication-format="electronic">2412-0677</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">863</article-id><article-id pub-id-type="doi">10.17816/ps863</article-id><article-id pub-id-type="edn">RBWJFS</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">A water-soluble contrast agent applied in a neonate with cystic fibrosis-related meconium ileus: a case report</article-title><trans-title-group xml:lang="ru"><trans-title>Использование водорастворимого контрастного вещества у новорождённого с мекониальным илеусом на фоне муковисцидоза: клиническое наблюдение</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-0709-2213</contrib-id><contrib-id contrib-id-type="spin">6488-3900</contrib-id><name-alternatives><name xml:lang="en"><surname>Shvalev</surname><given-names>Fedor M.</given-names></name><name xml:lang="ru"><surname>Швалев</surname><given-names>Федор Михайлович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>aesthetic@list.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9050-3629</contrib-id><contrib-id contrib-id-type="spin">7466-8731</contrib-id><name-alternatives><name xml:lang="en"><surname>Tsap</surname><given-names>Natalya A.</given-names></name><name xml:lang="ru"><surname>Цап</surname><given-names>Наталья Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>tsapna-ekat@rambler.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4306-1378</contrib-id><contrib-id contrib-id-type="spin">1789-4251</contrib-id><name-alternatives><name xml:lang="en"><surname>Chudakov</surname><given-names>Vladislav B.</given-names></name><name xml:lang="ru"><surname>Чудаков</surname><given-names>Владислав Борисович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>vb.chudakov@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Ural State Medical University</institution></aff><aff><institution xml:lang="ru">Уральский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Regional Children Hospital, Ekaterinburg</institution></aff><aff><institution xml:lang="ru">Областная детская клиническая больница, Екатеринбург</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-10-31" publication-format="electronic"><day>31</day><month>10</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-11-28" publication-format="electronic"><day>28</day><month>11</month><year>2025</year></pub-date><volume>29</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>338</fpage><lpage>345</lpage><history><date date-type="received" iso-8601-date="2025-04-09"><day>09</day><month>04</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-10-13"><day>13</day><month>10</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Shvalev F.M., Tsap N.A., Chudakov V.B.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Shvalev F.M., Tsap N.A., Chudakov V.B.</copyright-holder><copyright-holder xml:lang="ru">Эко-вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2026-11-28"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://eco-vector.com/for_authors.php#07</ali:license_ref></license></permissions><self-uri xlink:href="https://jps-nmp.ru/jour/article/view/863">https://jps-nmp.ru/jour/article/view/863</self-uri><abstract xml:lang="en"><p>Meconium ileus presents a serious challenge in the newborn period, requiring timely diagnosis and effective management. New conservative curative modalities can improve outcomes and reduce the need for surgical interventions, especially in newborns.</p> <p>The article discusses a case of preterm newborn boy with meconium ileus diagnosed on the second day of his life. Water-soluble contrast on resistant starch and iopromide could resolve intestinal obstruction without any surgical intervention. Contrast passage lasted for 24 hours and was followed by spontaneous stool. No electrolyte disorders were detected during the manipulation. Enteral insufficiency was eliminated, and the child was discharged home on the 14th day of his life with positive weight dynamics. Irrigography showed no evidence of Hirschprung’s disease. Genetic examination confirmed that the child was a carrier of cystic fibrosis gene.</p> <p>Thus, water-soluble contrast with resistant starch is a new approach that can potentially improve the effectiveness of conservative treatment of meconium ileus in newborns. Resistant starch reduces systemic iodine exposure and improves bowel motility. The discussed technique is a valuable addition to the existing approaches in treating meconial ileus which allows to avoid surgical intervention and its associated risks. Further research and clinical experience will define optimal protocols on the application of the described technique and its place in the algorithm of diagnosis and treatment of meconium ileus in newborns.</p></abstract><trans-abstract xml:lang="ru"><p>Мекониальный илеус представляет собой серьёзную проблему в период новорождённости, что требует своевременной диагностики и эффективного лечения. Применение новых методов консервативной терапии поможет улучшить результаты и снизить необходимость хирургического вмешательства, особенно у новорождённых детей.</p> <p>В статье представлен случай недоношенного новорождённого мальчика с мекониальным илеусом, диагностированным на вторые сутки жизни. Применение водорастворимого контрастного вещества на основе резистентного крахмала и йопромида привело к разрешению кишечной непроходимости без необходимости хирургического вмешательства. Пассаж контрастного вещества осуществлялся в течение 24 часов, после чего появился самостоятельный стул. Электролитных нарушений в период проведения манипуляции не выявлено. Энтеральная недостаточность была купирована, и ребёнок выписан домой на 14-й день жизни с положительной динамикой массы тела. При проведении ирригографии данных за наличие болезни Гиршпрунга не получено. По данным генетического обследования подтверждено носительство гена муковисцидоза.</p> <p>Таким образом, использование комбинации водорастворимого контрастного вещества на основе резистентного крахмала и йопромида представляет собой новый подход, который потенциально может повысить эффективность консервативного лечения мекониального илеуса у новорождённых. Резистентный крахмал помогает снизить системное воздействие йода и способствует улучшению моторики кишечника. Данная методика является ценным дополнением к существующим подходам лечения мекониального илеуса, так как помогает избежать хирургического вмешательства и связанных с ним рисков.</p> <p>Дальнейшие исследования и накопление клинического опыта позволят определить как оптимальные протоколы комбинированного применения водорастворимого контрастного вещества на основе резистентного крахмала и йопромида, так и место данного метода в алгоритме диагностики и лечения мекониального илеуса у новорождённых.</p></trans-abstract><kwd-group xml:lang="en"><kwd>meconium ileus</kwd><kwd>newborn</kwd><kwd>contrast</kwd><kwd>resistant starch</kwd><kwd>intestinal obstruction</kwd><kwd>case report</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>мекониальный илеус</kwd><kwd>новорождённые</kwd><kwd>водорастворимое контрастное вещество</kwd><kwd>резистентный крахмал</kwd><kwd>кишечная непроходимость</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Carlyle BE, Borowitz DS, Glick PL. 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