EXPERIMENTAL JUSTIFICATION OF THE USE OF SCLEROSANT AETOXISCLEROL IN THE TREATMENT OF HEMANGIOMA IN CHILDREN



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The aim of the study was to study the changes in tissues after interstitial administration of aethoxysclerol (5 and 10 mg/ml) in comparison with 70% ethanol in the experimental model of hemangioma (chicken caruncle). After the introduction of 70% ethyl alcohol into the chicken, disintegration of fibers and amorphous substancecaruncle from the 1st day, thrombosis of large and small vessels, perivascular edema of connective tissue were detected. By the 14th day, there was observed necrosis of the caruncle tooth, into which ethanol was injected. By the 21st day, under the area of necrosis, in the part of the scallop, a coarse keloid scar was formed with deformation of the tissues. Introduction of aethoxiclerol in dose of 5 mg/ml into the caruncle led to the compaction of the structure of the caruncle due to the proliferation of fibrous tissue. Partial thrombosis of small and large vessels of both superficial and deep layers of the caruncle was observed with a small number of inflammatory cells. By the 21st day, the compaction of the tissues was combined with the large-lamellar desquamation of the caruncle on the site of infiltration of the drug without necrosis. In the fibrous-fat layer, there was a substitution of fat tissue by fibrous, which was distributed evenly. In the dynamics, there was an increase in the compaction of all the layers of the caruncle without formation of the coarse scar tissue. An increase in the dose of aethoxysclerol to 10 mg/ml was accompanied by necrosis and gross morphological changes, similar to the administration of 70% ethanol.

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N. Okunev

N.P. Ogarev National Research Mordovia State University; Children Republic Clinical Hospital

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A. Okuneva

N.P. Ogarev National Research Mordovia State University

Email: ToropkinaOkuneva@yandex.ru
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V. Balashov

N.P. Ogarev National Research Mordovia State University

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O. Shchekin

Children Republic Clinical Hospital

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