A modern view at the treatment of ectopic pancreas in the gastro-duodenal zone in children (a literature review)
- Authors: Rumyantseva G.N.1, Kazakova E.I.1, Brevdo Y.F.2, Kazakov A.N.1
-
Affiliations:
- Tver State Medical University
- Regional Children’s Clinical Hospital
- Issue: Vol 26, No 1 (2022)
- Pages: 18-23
- Section: REVIEWS
- Submitted: 11.04.2022
- Accepted: 11.04.2022
- Published: 11.04.2022
- URL: https://jps-nmp.ru/jour/article/view/434
- DOI: https://doi.org/10.55308/1560-9510-2022-26-1-18-23
- ID: 434
Cite item
Abstract
Introduction. Ectopic pancreas (EP) in children is a rare malformation. In the pediatric practice, it is rarely manifested with a pain syndrome. Although most ectopia cases are asymptomatic, some children have signs of the disease at an early age what may require a surgical intervention.
Material. The researchers have analyzed domestic and foreign literature on the pancreatic ectopia in the gastro-duodenal zone which was published over the past 20 years and up to the present. The literature search with key words was done at such search engines as: Library, eLibrary, PubMed, Medline. The researchers analyzed the most important works published in the last century.
Results. A review of 32 literature sources with data on epidemiology, classification, origin, diagnostics and treatment of ectopic pancreas in the gastro-duodenal zone is presented in the article. This paper specifically draws attention to a minimally invasive surgery for the radical correction of this congenital malformation.
Conclusion. Surgical intervention is required for patients with a marked pain symptom after ineffective conservative treatment. The aim of surgery is to perform layered resection of the stomach wall in which the ectopic pancreatic tissue is located.
Keywords
About the authors
G. N. Rumyantseva
Tver State Medical University
Email: fake@neicon.ru
ORCID iD: 0000-0001-6709-0352
170100 Tver
РоссияE. I. Kazakova
Tver State Medical University
Author for correspondence.
Email: sei24021991@mail.ru
ORCID iD: 0000-0002-8243-3584
Elena I. Kazakova, post-graduate student at the department of Pediatric Surgery
170100 Tver
РоссияYu. F. Brevdo
Regional Children’s Clinical Hospital
Email: fake@neicon.ru
ORCID iD: 0000-0001-5623-1500
170100 Tver
РоссияA. N. Kazakov
Tver State Medical University
Email: fake@neicon.ru
ORCID iD: 0000-0001-5766-0841
170100 Tver
РоссияReferences
- Kilius A., Samalavicius N.E., Danys D., Zaldokas G., Seinin D. Asymptomatic heterotopic pancreas in Meckel’s diverticulum: a case report and review of the literature. Journal of medical case reports. 2015; (9): 108. https://doi.org/10.1186/s13256-015-0576-x
- Румянцева Г.Н., Минько Т.Н., Трухачев С.В., Бревдо Ю.Ф., Светлов В.В., Галахова Д.Г. Диагностика и лечение эктопированной поджелудочной железы у детей. Детская хирургия. 2013. (1): 34–6. Rumyantseva G.N., Minko T.N., Trukhachev S.V., Brevdo Yu.F., Svetlov V.V., Galakhova D.G. Diagnosis and treatment of ectopic pancreas in children. Detskaya khirurgiya. 2013; (1): 34–6. (in Russian)
- Kapur S., Mahal P., Miles L., Hussain A. Diagnosing a gastric submucosal tumor using jumbo biopsy «unroofing» technique: a case report and review of the literature. Case reports in oncological medicine. 2013; 414518. https://doi.org/10.1155/2013/414518
- Винокурова Н.В., Цап Н.А., Дружинин Ю.В., Валамина И.Е., Огнев С.И. Клинико-эндоскопические и морфологические особенности эктопированной поджелудочной железы в стенку желудка у детей. Уральский медицинский журнал. 2012 (7): 68–72. Vinokurova N.V., Tsap N.A., Druzhinin Yu.V., Valamina I.Ye., Ognev S.I. Clinical and endoscopic and morphological features of the ectopic pancreas in the stomach wall in children. Ural’skiy meditsinskiy zhurnal. 2012 (7): 68–72. (in Russian)
- Бельмер С.В., Костырко Е.В., Приворотский В.Ф., Луппова Н.Е., Аберрантная поджелудочная железа у детей. Вопросы детской диетологии. 2013; 11 (3): 49–54. Belmer S.V., Kostyrko Ye.V., Privorotskiy V.F., Luppova N.Ye. Aberrant pancreas in children.Voprosy detskoy diyetologii. 2013; 11(3): 49–54. (in Russian)
- Киримов Р.Я., Наливкин А.Е. Патент № 2495631 C1 Российская Федерация, МПК A61B 17/00. Способ лечения аберрантной поджелудочной железы, расположенной в желудке: № 2012123473/14: заявл. 07.06.2012: заявитель Государственное бюджетное учреждение здравоохранения Московской области «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского» (ГБУЗ МО МОНИКИ). Kirimov R.Ya., Nalivkin A.E. Patent No. 2495631 C1 Russian Federation, IPC A61B 17/00. Method of treatment of an aberrant pancreas located in the stomach: No. 2012123473/14: application 07.06.2012: applicant State Budgetary Healthcare Institution of the Moscow region «Moscow Regional Research Clinical Institute named after M.F. Vladimirsky» (GBUZ MO MONICA).
- Котляров П.М., Сергеев Н.И., Ребрикова В.А., Сурков С.В., Татарников О.В., Магнитно-резонансная и компьютерная томография в дифференциальной диагностике эктопии ткани поджелудочной железы и забрюшинной опухоли. Лучевая диагностика и терапия. 2017; 4(8): 54–9. Kotlyarov P.M., Sergeyev N.I., Rebrikova V.A., Surkov S.V., Tatarnikov O.V. Magnetic resonance imaging and computed tomography in the differential diagnosis of ectopia of pancreatic tissue and retroperitoneal tumor. Luchevaya diagnostika i terapiya. 2017; 4(8): 54–9. (in Russian)
- Гребенев А.Л. Аномалии поджелудочной железы. Руководство по гастроэнтерологии. Под ред. Ф.И. Комарова, А.Л. Гребенева. М.: Медицина, 1996; 3(5): 74–81. Grebenev A.L. Abnormalities of the pancreas. A guide to gastroenterology [Anomalii podzheludochnoi zhelezy. Rukovodstvo po gastroenterologii]. Ed F.I. Komarova, A.L. Grebeneva. Moscow: Meditcina, 1996; 3(5): 74–81. (In Russian)
- Białek A., Wiechowska–Kozłowska A., Pertkiewicz J., Karpińska K., Marlicz W., Milkiewicz P., Starzyńska T. Endoscopic submucosal dissection for the treatment of neoplastic lesions in the gastrointestinal tract. World journal of gastroenterology. 2013; 19(12): 1953–61. PMID: 23569341. PMCID: PMC3613111. https://doi.org/10.3748/wjg.v19.i12.1953
- Fukino N., Oida T., Mimatsu K., Kida K., Kawasaki A., Kuboi Y., Kano H. Diffuse Peritonitis due to Perforated Gastric Ectopic Pancreas. Case reports in gastroenterology. 2012; 6(3): 689–94. https://doi.org/10.1159/000345382
- Светлов В.В., Минько Т.Н., Румянцева Г.Н., Бревдо Ю.Ф., Трухачев С.В., Иванов П.С. Хористома у детей. Клиника, диагностика. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2020; 10(S): 146. Svetlov V.V., Minko T.N., Rumyantseva G.N., Brevdo Yu.F., Trukhachev S.V., Ivanov P.S., Choristoma in children. Clinic, diagnostics. Rossiyskiy vestnik detskoy khirurgii, anesteziologii i reanimatologii. 2020; 10(S): 146. (in Russian)
- Kim J.Y., Lee J.M., Kim K.W., Park H.S., Choi J.Y., Kim S.H., Kim M.A., Lee J.Y., Han J.K., Choi B.I. Ectopic pancreas: CT findings with emphasis on differentiation from small gastrointestinal stromal tumor and leiomyoma. Radiology. 2009 Jul; 252(1): 92–100. https://doi.org/10.1148/radiol.2521081441
- Винокурова Н.В. Диагностика и хирургическое лечение эктопии поджелудочной железы в стенку желудка у детей. Автореферат диссертации на соискание учёной степени кандидата медицинских наук. М.: 2008. Vinokurova N.V. Diagnosis and surgical treatment of pancreatic ectopia in the stomach wall in children; Abstract of the dissertation for the degree of Candidate of Medical Sciences [Diagnostika i khirurgicheskoye lecheniye ektopii podzheludochnoy zhelezy v stenku zheludka u detey; Avtoreferat dissertatsii na soiskaniye uchenoy stepeni kandidata meditsinskikh nauk]. Moscow: 2008. (in Russian)
- Iwahashi S., Nishi M., Yoshimoto T. et al. A case of gastric heterotopic pancreas with gastroduodenal invagination. Surg case rep. 2019; 5: 110. https://doi.org/10.1186/s40792-019-0669-7
- Singh D., Bansal R. Heterotopic Pancreas Presenting as Gastric Polyp. Surgical Science. 2014; 5: 135–7. https://doi.org/10.4236/ss.2014.54024
- Zhao Z., Sim C.K., Mantoo S. Heterotopic pancreas in the omphalomesenteric duct remnant in a 9-month-old girl: a case report and literature review. Diagnostic pathology. 2017; 12(1): 49. https://doi.org/10.1186/s13000-017-0643-2
- Shamoon D., Sostre V., Patel V., Volfson A. A Case of Heterotopic Pancreatic Tissue Discovered in the Distal Esophagus. Case reports in gastrointestinal medicine. 2020; 4695184. https://doi.org/10.1155/2020/4695184
- Elwir S., Glessing B., Amin K., Jensen E., Mallery S. Pancreatitis of ectopic pancreatic tissue: a rare cause of gastric outlet obstruction. Gastroenterology report. 2017; 5(3): 237–40. https://doi.org/10.1093/gastro/gov037
- Yang C.W., Che F., Liu X.J., Yin Y., Zhang B., Song B. Insight into gastrointestinal heterotopic pa. 2021; 12(1): 144. https://doi.org/10.1186/s13244-021-01089-0
- Vyawahare M.A., Musthyla N.B. Ectopic pancreas at the ampulla of Vater diagnosed with endoscopic snare papillectomy: A case report and review of literature. World journal of gastrointestinal endoscopy. 2021; 13(9): 437–46. https://doi.org/10.4253/wjge.v13.i9.437
- Sharma D.K., Agarwal S., Saran R.K., Agarwal A.K. Pseudocyst of ectopic pancreas of the duodenal wall masquerading as malignant cystic tumor of pancreas. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. 2009; 15(4): 271–3. https://doi.org/10.4103/1319-3767.56101
- Monier A., Awad A., Szmigielski W., Muneer M., Alrashid A., Darweesh A., Hassan H. Heterotopic pancreas: a rare cause of ileoileal intussusception. Polish journal of radiology. 2014; 79: 349–51. https://doi.org/10.12659/PJR.890913
- Song D.E., Kwon Y., Kim K.R., Oh S.T., Kim J.S. Adenocarcinoma arising in gastric heterotopic pancreas: a case report. J Korean Med Sci. 2004 Feb; 19(1): 145–8. PMID: 14966359. PMCID: PMC2822253. https://doi.org/10.3346/jkms.2004.19.1.145
- Guimarães M., Rodrigues P., Gonçalves G., Nora M., Monteiro M.P. Heterotopic pancreas in excluded stomach diagnosed after gastric bypass surgery. BMC surgery. 2013; 13: 56. https://doi.org/10.1186/1471-2482-13-56
- Catalano F., Rodella L., Lombardo F., Silano M., Tomezzoli A., Fuini A., Di Cosmo M.A., de Manzoni G., Trecca A. Endoscopic submucosal dissection in the treatment of gastric submucosal tumors: results from a retrospective cohort study. Gastric Cancer. 2013 Oct; 16(4): 563–70. Epub 2012 Dec 28. PMID: 23271043. https://doi.org/10.1007/10120-012-0225-7
- Betzler A., Mees S.T., Pump J. et al. Clinical impact of duodenal pancreatic heterotopia – Is there a need for surgical treatment? BMC Surg. 2017; 17: 53. https://doi.org/10.1186/s12893-017-0250-x
- Bromberg S.H., Camilo Neto C., Borges A.F., Franco M.I., França L.C., Yamaguchi N. Pancreatic heterotopias: clinicopathological analysis of 18 patients. Rev Col Bras Cir. 2010 Dec; 37(6): 413–9. English, Portuguese. PMID: 21340256. https://doi/org/10.1590/s0100-69912010000600007
- Lee M.J., Chang J.H., Maeng I.H., Park J.Y., Im Y.S., Kim T.H., Han S.W., Lee D.S. Ectopic pancreas bleeding in the jejunum revealed by capsule endoscopy. Clin Endosc. 2012 Sep; 45(3): 194–7. Epub 2012 Aug 22. PMID: 22977800. PMCID: PMC3429734. https://doi.org/10.5946/ce.2012.45.3.194
- Papaziogas B., Koutelidakis I., Tsiaousis P., Panagiotopoulou K., Paraskevas G., Argiriadou H., Atmatzidis S., Atmatzidis K. Carcinoma developing in ectopic pancreatic tissue in the stomach: a case report. Cases journal. 2008 Oct 18; 1(1): 249. PMID: 18928565. PMCID: PMC2577107. https://doi.org/10.1186/1757-1626-1-249
- Menon L., Buscaglia J.M. Endoscopic approach to subepithelial lesions. Therapeutic advances in gastroenterology. 2014; 7(3): 123–30. https://doi.org/10.1177/1756283X13513538
- Сварич В.Г., Лисицын Д.А., Ислентьев Р.Н., Перевозчиков Е.Г., Каганцов И.М., Особенности диагностики и лечения хористомы желудка у детей. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2018; 8(2): 73–8. Svarich V.G, Lisitsyn D.A, Islentyev R.N, Perevozchikov Ye.G, Kagantsov I.M. Features of diagnosis and treatment of gastric choristoma in children. Rossiyskiy vestnik detskoy khirurgii, anesteziologii i reanimatologii. 2018; 8(2): 73–8. (in Russian)
- Соколов Ю.Ю., Ефременков А.М., Зыкин А.П., Туманова Е.Л., Омарова Ж.Р., Антонова Д.В., Ахматов Р.А. Кистозные удвоения желудка с локализацией в поджелудочной железе у детей. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2020; 10(1): 35–42. Sokolov Yu.Yu., Yefremenkov A.M., Zykin A.P., Tumanova Ye.L., Omarova Zh.R., Antonova D.V., Akhmatov R.A. Cystic doubling of the stomach with localization in the pancreas in children. Rossiyskiy vestnik detskoy khirurgii, anesteziologii i reanimatologii. 2020; 10(1): 35–42. (in Russian)