Anesthetic and medical properties of xenon in the preparation of children for plastic wound closure


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Abstract

Introduction. The authors present their experience in experimental and clinical studies on the application of Xenon (Xe) in subnarcotic concentrations for pain relief and for the treatment of acute stress disorders. Preparing wounds for plastic closure in children is a long and painful process which requires many anesthesia procedures during dressings. It leads to cognitive disorders, affects memory and learning potentials. Every third child who survived a severe trauma suffers of acute stress disorders: bad sleep, emotional imbalance, anxiety, asociality, inappropriate actions. Xenon is a non-toxic anesthetic. In the concentration of 20–50%, it is not only anesthetizes, but also decreases acute stress disorders, has sedative and anti-stress effects and normalizes sleep.
Objectives. To study literature data on the potentials of gas Xe in subnarcotic concentrations for pain relief and for decreasing acute stress disorders at the stage of preparing a child for plastic closure of a wound defect.
Material and methods. Literature search was done in PubMed, Scopus, eLIBRARY, Cyberleninka in English and Russian using key words: “Xenon”, “Xenon and anesthesia”, “Xenontherapy” “Actions of Xenon”, “Treatment of extensive wounds in children”, “Acute stress disorders”.
Results. The analysis of the data of the conducted studies showed the non-toxicity of Xe, which makes it possible to use it repeatedly for anesthesia in children. The fact that Xe reduces the manifestations of anxiety, depressive and psychosomatic symptoms in patients with acute and chronic stress disorders allows us to count on its positive effects in the treatment of children with extensive wounds of traumatic origin at the stage of preparing them for plastic closure.
Conclusion. The practical absence in the available scientific literature of a study to assess the effectiveness of the use of subnarcotic concentrations of Xe, when dressing extensive wounds at the stage of preparation of the wound process for plastic closure in children with acute stress disorders, justifies the conduct of an appropriate scientific study.

About the authors

N. G. Raushenbakh

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma

Author for correspondence.
Email: fake@neicon.ru

119180, Moscow

Russian Federation

V. G. Bagaev

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma; Russian Medical Academy for Continuous Post-Diploma Education

Email: bagaev61@mail.ru

Vladimir G. Bagaev, leading researcher, intensive care department

119180, Moscow

123242, Moscow

Russian Federation

V. G. Amcheslavsky

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma

Email: fake@neicon.ru

119180, Moscow

Russian Federation

T. F. Ivanova

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma

Email: fake@neicon.ru

119180, Moscow

Russian Federation

A. Yu. kyzy Dzhanmirzoeva

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma

Email: fake@neicon.ru

119180, Moscow

Russian Federation

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