Venous thromboembolitic complications in children and adults with permanent venous access (literature review)


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Abstract

Introduction. Over the past decades, permanent venous access devices, in particular port systems and peripherally implanted central catheters, has been increasingly introduced in adult and pediatric oncology. As far as central catheters and permanent access devices are foreign bodies in basic veins, quite naturally that they are one more risk factor for thrombosis.
Material and methods. The authors searched literature data ( in Russian and English) for the period up to May 3, 2022 using public databases (Embase, Medline/PubMed, Researchgate, medrxiv.org, RSCI/eLibrary). The following keywords were used for the search: “port-system”, “peripherally implanted central catheter”, “totally implanted vascular access device”, “venous thromboembolism”, “VTE”, “venous thromboembolic complications”, “VTEC”, “catheter dysfunction”, “device malfunction”. Available preprints, articles with “in press” or “online first” status, and clinical cases were also included in the analysis.
Conclusion. This review discusses prevention, diagnostics and treatment of venous thromboembolic complications in cancer patients using similar implantable devices. In patients with catheter-associated thromboses, of practical interest are various diagnostic and curative algorithms, recommendations on the choice of vascular access, medicamentous therapy as well as variants of surgical intervention.

About the authors

M. A. Cherkashin

Medical and Diagnostic Center of the International Institute of Biological Systems named after Sergey Berezin

Author for correspondence.
Email: mc@ldc.ru
ORCID iD: 0000-0002-5113-9569

Mikhail А. Cherkashin, Deputy Chief Medical Officer, Surgeon

191144, St. Petersburg

Russian Federation

S. V. Alexandrov

Medical and Diagnostic Center of the International Institute of Biological Systems named after Sergey Berezin

Email: fake@neicon.ru
ORCID iD: 0000-0002-4429-5723

191144, St. Petersburg

Russian Federation

T. V. Bolshakova

Medical and Diagnostic Center of the International Institute of Biological Systems named after Sergey Berezin

Email: fake@neicon.ru
ORCID iD: 0000-0002-0757-4862

191144, St. Petersburg

Russian Federation

A. A. Nikolaev

Medical and Diagnostic Center of the International Institute of Biological Systems named after Sergey Berezin

Email: fake@neicon.ru
ORCID iD: 0000-0001-7337-2495

191144, St. Petersburg

Russian Federation

K. F. Boyko

Medical and Diagnostic Center of the International Institute of Biological Systems named after Sergey Berezin

Email: fake@neicon.ru
ORCID iD: 0000-0003-3293-0061

191144, St. Petersburg

Russian Federation

N. A. Berezina

Medical and Diagnostic Center of the International Institute of Biological Systems named after Sergey Berezin

Email: fake@neicon.ru
ORCID iD: 0000-0001-9772-4387

191144, St. Petersburg

Russian Federation

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