Serum osteocalcin concentration in children with craniosynostosis

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Abstract

BACKGROUND: The present study is an actual one because up to now there are no standards for craniosynostosis diagnostics and no simple and safe techniques for it. Osteocalcin concentration in the blood serum is an important marker of bone metabolism, that is why this parameter was chosen as a potential laboratory marker of craniosynostosis.

AIM: To determine osteocalcin concentrations in the blood serum of children with various forms of craniosynostosis.

METHODS: 94 children with craniosynostosis who were treated in the pediatric neurosurgical department of the Federal Center for Neurosurgery of the Ministry of Health of the Russian Federation (Novosibirsk, Russia) from November 2018 to March 2022 were included in the trail. Inclusion criteria were: age up to 6 complete years, children with syndromic and non-syndromic forms of craniosynostosis. The obtained findings were analyzed in two age groups: up to 6 months and over 6 months because of different reference values.

RESULTS: 8 children out of 60, aged 6 months-6 years, had the increased osteocalcin concentration in the serum (13.3%).

CONCLUSION: No correlation has been revealed between craniosynostosis and increased serum osteocalcin concentrations in children under 6 years of age.

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About the authors

Alexander V. Shcherbakov

Federal Center of Neurosurgery

Author for correspondence.
Email: sherba1984@mail.ru
ORCID iD: 0000-0001-6057-4805
SPIN-code: 5176-3229

MD

Россия, 132/1 Nemirovich-Danchenko street, 630087 Novosibirsk

Yulia F. Stashko

Federal Center of Neurosurgery

Email: j_stashko@neuronsk.ru
ORCID iD: 0009-0008-1342-9232

MD

Россия, 132/1 Nemirovich-Danchenko street, 630087 Novosibirsk

Sergey A. Kim

Federal Center of Neurosurgery

Email: s_kim@neuronsk.ru
ORCID iD: 0000-0002-9957-8122
SPIN-code: 4794-3568

MD

Россия, 132/1 Nemirovich-Danchenko street, 630087 Novosibirsk

Vasily E. Danilin

Federal Center of Neurosurgery

Email: v_danilin@neuronsk.ru
ORCID iD: 0000-0002-7115-0159
SPIN-code: 9336-4966

MD

Россия, 132/1 Nemirovich-Danchenko street, 630087 Novosibirsk

German V. Letyagin

Federal Center of Neurosurgery

Email: g_letyagin@neuronsk.ru
ORCID iD: 0000-0001-5564-6130
SPIN-code: 6437-0871

MD, Cand. Sci. (Medicine)

Россия, 132/1 Nemirovich-Danchenko street, 630087 Novosibirsk

Evgenia V. Amelina

Federal Center of Neurosurgery

Email: amelina.evgenia@gmail.com
ORCID iD: 0000-0001-7537-3846
SPIN-code: 8814-0913

MD, Cand. Sci. (Physics and Mathematics)

Россия, 132/1 Nemirovich-Danchenko street, 630087 Novosibirsk

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2. Fig. 1. Serum osteocalcin concentration depending on the sex of the child: Ж — female sex; М — male sex.

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3. Fig. 2. Distribution of serum osteocalcin concentration depending on the age and gender of the child: Ж до года — girls under 1 year of age; М до года — boys under 1 year of age; Ж год+ — girls aged 1 year and older; М год+ — boys aged from 1 year.

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4. Fig. 3. Serum osteocalcin concentration of patients with synostosis and without synostosis of the skull sutures: Ж — girls without synostosis; M — boys without synostosis; Ж + — girls with synostosis; M + — boys with synostosis.

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5. Fig. 4. Serum osteocalcin concentration in children under 6 months depending on sex: Ж — female sex; М — male sex.

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Copyright (c) 2024 Shcherbakov A.V., Stashko Y.F., Kim S.A., Danilin V.E., Letyagin G.V., Amelina E.V.