MORPHOLOGICAL CHANGES IN THE MUSCLE LAYERS OF SMALL INTESTINE IN THE SHORT BOWEL SYNDROME IN EXPERIMENT



如何引用文章

全文:

详细

Introduction. Patients with the short bowel syndrome often have intestinal dilatation which impairs intestinal functions. Changes in the muscle intestinal layers, which cause this condition, are not studied well yet. Purpose. To study the role of small intestine muscle layers in the intestinal adaptation and dilatation in the short bowel syndrome. Materials and methods. 22 rats were taken into the experimental trial; short bowel syndrome was modelled in 12 of them; 10 other rats which had only laparotomy were in the control group. The diameter and thickness of muscle layers in the small intestine and ileum were studied. Results. In the short bowel syndrome, one can observe a significant dilatation of the small intestine and ileum. Thickness of longitudinal and circular layers of the small intestine was significantly larger in rats with the short bowel syndrome in comparison to the control group. In the ileum, only the circular muscle layer was hypertrophied; there was no difference in the thickness of longitudinal muscle layer in rats with the short bowel syndrome and in rats from the control group. Conclusion. In rats with the short bowel syndrome, morphological changes occur not only in the mucous layer, but also in muscle layers of the small intestine what is manifested by the intestinal dilatation and hypertrophy of muscle layers. These changes are results of intestinal adaptation and are pathophysiological for the short bowel syndrome.

作者简介

R. Khasanov

Department of Pediatric Surgery with a course of additional vocational education, Bashkir State Medical University; Department of Pediatric Surgery, University of Mannheim, Clinical Faculty of Heidelberg

编辑信件的主要联系方式.
Email: noemail@neicon.ru
俄罗斯联邦

D. Svoboda

Department of Pediatric Surgery, University of Mannheim, Clinical Faculty of Heidelberg

Email: noemail@neicon.ru
俄罗斯联邦

M. Kohl

Department of Pediatric and Adolescent Medicine, University Medical Center Schleswig- Holstein

Email: noemail@neicon.ru
俄罗斯联邦

A. Gumerov

Department of Pediatric Surgery with a course of additional vocational education, Bashkir State Medical University

Email: pedsurg@bk.ru
ORCID iD: 0000-0001-6183-8286
俄罗斯联邦

V. Vagapova

Department of Human Anatomy of Bashkir State Medical University

Email: noemail@neicon.ru
俄罗斯联邦

R. Gumerov

Department of Pediatric Surgery with a course of additional vocational education, Bashkir State Medical University

Email: noemail@neicon.ru
俄罗斯联邦

L. Wessel

Department of Pediatric Surgery, University of Mannheim, Clinical Faculty of Heidelberg

Email: noemail@neicon.ru
俄罗斯联邦

参考

  1. Rege A.S., Sudan D.L. Autologous Gastrointestinal Reconstruction: Review of the Optimal Nontransplant Surgical Options for Adults and Children With Short Bowel Syndrome. Nutr Clin Pract, 2012
  2. Розинов М.В., Чубарова А.И., Ерпулева Ю.В., Аверьянова Ю.В., Демура С.А., Косов Д.А. российский регистр детей с синдромом «короткой кишки». Российский вестник детской хирургии, анестезиологии и реаниматологии. 2017; 7(4): 38-45
  3. Weih S., et al. Current practice and future perspectives in the treatment of short bowel syndrome in children-a systematic review. Langenbecks Arch Surg, 2012; 397(7): 1043-51.
  4. Nucci A., et al., Interdisciplinary management of pediatric intestinal failure: A 10-year review of rehabilitation and transplantation. Journal of Gastrointestinal Surgery/ 2008; 12(3): 429-35.
  5. Olieman J.F., et al. Impact of infantile short bowel syndrome on long-term health-related quality of life: a cross-sectional study. J. Pediatr. Surg. 2012; 47(7): 1309-16.
  6. Duro,D., Kamin D., Duggan C. Overview of pediatric short bowel syndrome. J Pediatr Gastroenterol Nutr. 2008; 47 (Suppl 1): 33-6.
  7. Хасанов Р.Р., Гумеров А.А., Вессель Л.М. причины развития синдрома короткой кишки. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2017; 7(3): 8-12.
  8. Аверьянова Ю.В., Степанов А.Э., Разумовский А.Ю., Поляев Ю.А., Макаров С.П., Васильев К.Г., Бологов А.А., Ашманов К.Ю., Мызин А.В., Исаева М.В., Бурмистров И.Ю., Кочкин В.С., Брюсов Г.П., Рогожин Д.В., Эктова А.П. успешное лечение синдрома короткой кишки у ребенка с обширной инфантильной гемангиомой брюшной полости. Детская хирургия. 2015; 19(6): 50-3.
  9. Чепурной М. Г., Чепурной Г.И., Кацупеев В.Б., Арутюнов А.В., Лейга А.В., Дмитриев С.Г., Варичева Н.В., Астахов Р.Е., Семешин А.В., Лукаш Ю.В. Гастрошизис в сочетании с множественными пороками развития кишечника. Детская хирургия. 2018; 22(2): 109-11.
  10. Wales P.W., Christison-Lagay E.R. Short bowel syndrome: epidemiology and etiology. Semin Pediatr Surg. 2010; 19(1): 3-9
  11. Тимербулатов В.М., Тимербулатов Ш.В., Асманов Д.И., Асманов Д.И., Султанабаев А.У. диагностика ишемических повреждений кишечника при некоторых острых хирургических заболеваниях органов брюшной полости. Креативная хирургия и онкология. 2017; 7(3): 12-9. https://doi.org/10.24060/2076-3093-2017-7-3-12-19
  12. Goulet O., Sauvat F. Short bowel syndrome and intestinal transplantation in children. Curr Opin Clin Nutr Metab Care, 2006; 9(3): 304-13.
  13. Oliveira C., N. de Silva, Wales P.W. Five-year outcomes after serial transverse enteroplasty in children with short bowel syndrome. J Pediatr Surg. 2012; 47(5): 931-7.
  14. Ерпулёва Ю.В., Чубарова А.И., Вайнштейн Н.П., Британишская Е.А., Митина Ю.Ю. осложнения длительного парентерального питания новорожденных и детей грудного возраста. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2017; 7(1): 59-69
  15. O’Brien D.P., et al. Intestinal adaptation: structure, function, and regulation. Semin Pediatr Surg. 2001; 10(2): 56-64.
  16. Martin C.A., et al. Resection-induced intestinal adaptation and the role of enteric smooth muscle. J Pediatr Surg. 2008; 43(6): 1011-7.
  17. Stephens A.N., et al. Proteomic analysis of the intestinal adaptation response reveals altered expression of fatty acid binding proteins following massive small bowel resection. J Proteome Res. 2010; 9(3): 1437-49.
  18. Goulet, O. and F. Ruemmele. Causes and management of intestinal failure in children. Gastroenterology. 2006; 130(2 Suppl 1): 16-28.
  19. Chen J., Wen J., Cai W. Smooth muscle adaptation and recovery of contractility after massive small bowel resection in rats. Exp Biol Med (Maywood). 2012; 237(5): 578-84.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © , 2019

##common.cookie##