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MORPHOLOGICAL CHANGES IN THE MUSCLE LAYERS OF SMALL INTESTINE IN THE SHORT BOWEL SYNDROME IN EXPERIMENT
- Authors: Khasanov R.R.1,2, Svoboda D...2, Kohl M...3, Gumerov A.А.1, Vagapova V.S.4, Gumerov R.A.1, Wessel L.M.2
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Affiliations:
- Department of Pediatric Surgery with a course of additional vocational education, Bashkir State Medical University
- Department of Pediatric Surgery, University of Mannheim, Clinical Faculty of Heidelberg
- Department of Pediatric and Adolescent Medicine, University Medical Center Schleswig- Holstein
- Department of Human Anatomy of Bashkir State Medical University
- Issue: Vol 23, No 4 (2019)
- Pages: 176-180
- Section: ORIGINAL ARTICLES
- Submitted: 05.03.2021
- Published: 05.08.2019
- URL: https://jps-nmp.ru/jour/article/view/152
- DOI: https://doi.org/10.18821/1560-9510-2019-23-4-176-180
- ID: 152
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Abstract
Introduction. Patients with the short bowel syndrome often have intestinal dilatation which impairs intestinal functions. Changes in the muscle intestinal layers, which cause this condition, are not studied well yet. Purpose. To study the role of small intestine muscle layers in the intestinal adaptation and dilatation in the short bowel syndrome. Materials and methods. 22 rats were taken into the experimental trial; short bowel syndrome was modelled in 12 of them; 10 other rats which had only laparotomy were in the control group. The diameter and thickness of muscle layers in the small intestine and ileum were studied. Results. In the short bowel syndrome, one can observe a significant dilatation of the small intestine and ileum. Thickness of longitudinal and circular layers of the small intestine was significantly larger in rats with the short bowel syndrome in comparison to the control group. In the ileum, only the circular muscle layer was hypertrophied; there was no difference in the thickness of longitudinal muscle layer in rats with the short bowel syndrome and in rats from the control group. Conclusion. In rats with the short bowel syndrome, morphological changes occur not only in the mucous layer, but also in muscle layers of the small intestine what is manifested by the intestinal dilatation and hypertrophy of muscle layers. These changes are results of intestinal adaptation and are pathophysiological for the short bowel syndrome.
About the authors
R. R. Khasanov
Department of Pediatric Surgery with a course of additional vocational education, Bashkir State Medical University; Department of Pediatric Surgery, University of Mannheim, Clinical Faculty of Heidelberg
Author for correspondence.
Email: noemail@neicon.ru
Россия
D. .. Svoboda
Department of Pediatric Surgery, University of Mannheim, Clinical Faculty of Heidelberg
Email: noemail@neicon.ru
Россия
M. .. Kohl
Department of Pediatric and Adolescent Medicine, University Medical Center Schleswig- Holstein
Email: noemail@neicon.ru
Россия
A. А. Gumerov
Department of Pediatric Surgery with a course of additional vocational education, Bashkir State Medical University
Email: pedsurg@bk.ru
ORCID iD: 0000-0001-6183-8286
Россия
V. S. Vagapova
Department of Human Anatomy of Bashkir State Medical University
Email: noemail@neicon.ru
Россия
R. A. Gumerov
Department of Pediatric Surgery with a course of additional vocational education, Bashkir State Medical University
Email: noemail@neicon.ru
Россия
L. M. Wessel
Department of Pediatric Surgery, University of Mannheim, Clinical Faculty of Heidelberg
Email: noemail@neicon.ru
Россия
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