Jadassohn's nevus in a newborn: surgical treatment or conservative tactics

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BACKGROUND: Jadassohn's nevus (seborrheic nevus, nevus of the sebaceous glands) is a hamartoma which is mainly localized on the scalp and face skin. At birth, it looks like a barely noticeable light yellow plaque which significantly increases at the puberty period under androgenic stimulation. The histological picture of Jadasson's nevus is characterized by changes in the epidermis in the form of acanthosis, papillomatosis, hyperkeratosis, and a large number of hyperplastic sebaceous glands. Pluripotent epithelial cells, which are part of the hamartoma, may provoke the growth of secondary benign and malignant tumors. This nevus may be manifested by Schimmelpenning–Feuerstein–Mims syndrome which can damage the nervous system and eyes. Currently, there are no uniform recommendations for the management of patients with Jadassohn's nevus.

CLINICAL CASE DESCRIPTION: In this article, we present our own experience of treating two children discussed pathology. The first boy had a radical surgery at the age of 16 days of life because of large dimensions of the nevus and a significant cosmetic defect. Removal of the formation at the neonatal period has prevented the development of rough postoperative scars and promoted good cosmetic outcome due to high elastic and regenerative properties of baby's skin. In the second child, Jadasson's nevus looked like a barely noticeable light yellow plaque; therefore, conservative tactics was chosen for this patient. Both children were consulted by a neurologist and an ophthalmologist who found no pathology in the nervous system and in the vision organs.

CONCLUSION: The described two clinical examples demonstrate the need for individual and multidisciplinary approaches in the management of patients with Jadasson's nevus. Active surgical tactics should be applied because of a significant cosmetic defect rather than for the prevention of malignant transformation which is met in less than 1% of cases.

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作者简介

Irina Karyakina

Morozov Children's Municipal Clinical Hospital

编辑信件的主要联系方式.
Email: kariyakina@mail.ru
ORCID iD: 0009-0002-4034-8776
SPIN 代码: 9711-9742

MD, Dr. Sci. (Medicine)

俄罗斯联邦, 4th Dobryninsky Lane 1/9, buil. 21, 119049 Moscow

Mikhail Rekhviashvili

Moscow Regional Center for Maternal and Child Health; Russian University of Medicine

Email: dr.rekhviashvili@yandex.ru
ORCID iD: 0000-0003-2256-6198
SPIN 代码: 8467-3155

MD, Cand. Sci. (Medicine)

俄罗斯联邦, 6 Mira street, 140014 Lyubertsy, Moscow region; Moscow

Irina Bazina

Morozov Children's Municipal Clinical Hospital

Email: mdgkb-facial@morozdgkb.ru
ORCID iD: 0000-0003-1116-2729
SPIN 代码: 1698-9752

MD, Cand. Sci. (Medicine)

俄罗斯联邦, 4th Dobryninsky Lane 1/9, buil. 21, 119049 Moscow

Nina Bogatyreva

Morozov Children's Municipal Clinical Hospital

Email: centrpath@yandex.ru
ORCID iD: 0000-0002-7786-5075
SPIN 代码: 2609-9662

MD

俄罗斯联邦, 4th Dobryninsky Lane 1/9, buil. 21, 119049 Moscow

Kristina Propletkina

The Russian National Research Medical University named after N.I. Pirogov

Email: kislinka2000@yandex.ru
ORCID iD: 0009-0000-4095-7614

MD

俄罗斯联邦, 1 street Ostrovityanova, 117997 Moscow

参考

  1. Garcias-Ladaria J, Cuadrado Rosón M, Pascual-López M. Epidermal nevi and related syndromes: Part 2: Nevi derived from adnexal structures. Actas Dermosifiliogr (Engl Ed). 2018;109(8):687–698. doi: 10.1016/j.ad.2018.05.004
  2. Wali GN, Felton SJ, McPherson T. Management of naevus sebaceous: A national survey of UK dermatologists and plastic surgeons. Clin Exp Dermatol. 2018;43(5):589–591. doi: 10.1111/ced.13422
  3. Baigrie D, Troxell T, Cook C. Nevus sebaceus. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482493/
  4. Zhuchkov MV, Bolshakova EE, Sonin DB, Rodionova SA. Dermatoscopic diagnostics of nevus sebaceous of Jadassohn. Vestnik dermatologii i venerologii. 2018;94(3):39–44. EDN: XXFTDN doi: 10.25208/0042-4609-2018-94-3-39-44
  5. Gu AK, Zhang XJ, Zhang LT, Ma FK. Nevus sebaceous at an unusual location: A rare presentation. Chin Med J (Engl). 2017;130(23):2897–2898. doi: 10.4103/0366-6999.219147
  6. Chepla KJ, Gosain AK. Giant nevus sebaceus: definition, surgical techniques, and rationale for treatment. Plastic Reconstruct Surg. 2012;130(2):296e–304e. doi: 10.1097/PRS.0b013e3182589df2
  7. Patel P, Malik K, Khachemoune A. Sebaceus and Becker’s nevus: Overview of their presentation, pathogenesis, associations, and treatment. Am J Clin Dermatol. 2015;16(3):197–204. doi: 10.1007/s40257-015-0123-y
  8. Maldonado D, Hanson F, Layher H, Tarbox M. Neurofibroma within a nevus sebaceus: A case report. Cureus. 2022;14(8):e28645. EDN: ZERHQC doi: 10.7759/cureus.28645
  9. Lihua J, Feng G, Shanshan M, et al. Somatic KRAS mutation in an infant with linear nevus sebaceous syndrome associated with lymphatic malformations: A case report and literature review. Medicine (Baltimore). 2017;96(47):e8016. doi: 10.1097/MD.0000000000008016
  10. Kamyab-Hesari K, Seirafi H, Jahan S, et al. Nevus sebaceus: A clinicopathological study of 168 cases and review of the literature. Int J Dermatol. 2015;55(2):193–200. doi: 10.1111/ijd.12845
  11. Gaidina TA, Dvornikov AS, Skripkina PA, Arutyunyan GB. Rationale for removing nevus sebaceus of jadassohn in young patients. Bulletin Russ State Med University. 2018;(3):80–83. EDN: VBFWJQ doi: 10.24075/vrgmu.2018.033
  12. Morimura S, Tomita Y, Ansai S, Sugaya M. Secondary malignant tumors arising in nevus sebaceus: Two case reports. Diagnostics. 2022;12(6):1448. EDN: SXLQOM doi: 10.3390/diagnostics12061448
  13. Lobato-Berezo A, Aguilera-Peiró P, Pujol-Vallverdú RM. Tumor collision over sebaceous nevus: Clues for dermoscopic diagnosis. Actas Dermosifiliogr (Engl Ed). 2018;109(7):647–648. doi: 10.1016/j.ad.2017.04.034
  14. El Ezzi O, de Buys Roessingh AS, Bigorre M, Captier G. Syndromic sebaceous nevus: Current findings. Int J Dermatol. 2018;57(5):599–604. doi: 10.1111/ijd.13942
  15. Westfried M, Mikhail GR. Multifocal basal-cell carcinomas in a nevus sebaceus of Jadassohn. J Dermatol Surg Oncol. 1981;7(5):420–422. doi: 10.1111/j.1524-4725.1981.tb00668.x
  16. Idriss MH, Elston DM. Secondary neoplasms associated with nevus sebaceus of Jadassohn: A study of 707 cases. J Am Academ Dermatol. 2014;70(2):332–337. doi: 10.1016/j.jaad.2013.10.004

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1. JATS XML
2. Fig. 1. View of the patient at 5 day age: a — the right temporal region; b — the right temporoparietal region.

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3. Fig. 2. View of the patient a�er biopsy: a — the right temporal region; b — the right temporoparietal region, the formation has been partially removed.

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4. Fig. 3. Macroscopic picture of the removed fragment of the formation.

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5. Fig. 4. Microscopic picture of the bioptat: a, b, e — epidermis with pronounced papillomatosis; a, b, d — epidermis with pronounced acanthosis and hyperkeratosis, formation of keratin pseudocysts; b, c — ulcerative foci and reactive inflammatory infiltration; b–d, f — large number of intradermal hyperplastic sebaceous glands; hematoxylin-eosin staining; magnification ×10 (a–c, e, f), ×40 (c).

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6. Fig. 5. Patient after surgery.

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7. Fig. 6. A child at the age of 2 years: a — the scar is covered with the hair under usual head position; b — the normotrophic lambdoid scar in the right temporoparietal region.

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8. Fig. 7. Patient at the age of 6 days.

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版权所有 © Karyakina I.A., Rekhviashvili M.G., Bazina I.G., Bogatyreva N.N., Propletkina K.D., 2024

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