Medical expulsive therapy in children with urolithiasis in the foreign practice: a literature review

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Abstract

Urolithiasis in children is a common disease nowadays. In many countries, medical expulsive therapy is actively used in such cases. The purpose of this research is to highlight principles and effectiveness of medical expulsive therapy, as well as advantages and disadvantages of α1-blockers over other pharmpreparations in children with urolithiasis. In the present review, the researchers have analyzed literature publications from 2004 to 2023. This systemic review was made using databases of Cochrane, PubMed, Web of Science, Scopus for the period from 2004 to 2023. The following Key words were used for search: urolithiasis, medical expulsive therapy. 32 full-text articles were included in the study.

While assessing results of medical expulsive therapy application in children with urolithiasis, it was noted that α1-blockers can significantly increase stone expulsion rate and reduce expulsion time. Side-effects of the discussed technique are insignificant. They include: headache, dizziness, orthostatic hypotension or nasal congestion. Medical expulsive therapy is reasonable for application due to its high efficiency and due to α1-blockers safety in children with urolithiasis. At present, adrenergic receptor blockers for medical expulsive therapy in children with urolithiasis are not allowed in Russia.

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About the authors

Ibragim A. Kyarimov

National Medical Research Center for Children's Health

Author for correspondence.
Email: ibragim.kyarimov@bk.ru
ORCID iD: 0000-0003-4529-9926
SPIN-code: 8417-8649

MD

Russian Federation, 2/62 Lomonosovsky avenue, 119296 Moscow

Sergey N. Zorkin

National Medical Research Center for Children's Health

Email: zorkin@nczd.ru
ORCID iD: 0000-0002-2731-5008
SPIN-code: 4762-8837

MD, Dr. Sci. (Medicine), Professor

Russian Federation, 2/62 Lomonosovsky avenue, 119296 Moscow

Antonina D. Lobanova

National Medical Research Center for Children's Health

Email: lobanova.ad@nczd.ru
ORCID iD: 0000-0001-7971-5073

MD

Russian Federation, 2/62 Lomonosovsky avenue, 119296 Moscow

Svetlana A. Kosobutskaya

National Medical Research Center for Children's Health

Email: kosobutskaia.sa@nczd.ru
ORCID iD: 0000-0002-5484-9574
SPIN-code: 2589-3752

MD, Cand. Sci. (Medicine)

Russian Federation, 2/62 Lomonosovsky avenue, 119296 Moscow

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Copyright (c) 2024 Kyarimov I.A., Zorkin S.N., Lobanova A.D., Kosobutskaya S.A.

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