Biomarkers of renal parenchymal damage in young children with congenital hydronephrosis: literature review

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Abstract

Enlargement of the renal cavity system in a fetus is revealed at prenatal ultrasound in 1–5% of cases and can be caused by congenital hydronephrosis due to pelvic-ureteral junction obstruction, which is one of the most common nosologies in the structure of obstructive uropathies in childhood. A high risk of renal function decrease at the preclinical stage of disease development dictates a need to create highly informative diagnostic programs and treatment algorithms aimed at preventing complications. In this review, we discuss results of studies on diagnostic and prognostic value of cytokine biomarkers which are of a great interest in congenital hydronephrosis in young children. They include: kidney injury molecule-1, vascular endothelial growth factor-A, monocyte chemoattractant protein-1, neutrophil gelatinase-associated lipocalin, interleukin-1. Literature search for this review was made in Web of Science, PubMed, Russian Science Citation Index, CyberLeninka, Scopus databases.

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About the authors

Vladislav N. Klimov

Saratov State Medical University named after V.I. Razumovsky

Author for correspondence.
Email: klimov.surg@mail.ru
ORCID iD: 0000-0002-1556-6010
SPIN-code: 9696-4736
Россия, Saratov

Lyudmila A. Deryugina

Saratov State Medical University named after V.I. Razumovsky

Email: dludmila1@yandex.ru
ORCID iD: 0000-0001-5525-8648
SPIN-code: 8583-6925

MD, Dr. Sci. (Medicine), Professor

Россия, Saratov

Elena I. Krasnova

Saratov State Medical University named after V.I. Razumovsky

Email: krasnovasaratov@yandex.ru
ORCID iD: 0000-0003-1060-9517
SPIN-code: 5483-0762

MD, Cand. Sci. (Medicine), Assoc. Professor

Россия, Saratov

Era B. Popyhova

Saratov State Medical University named after V.I. Razumovsky

Email: popyhovaeb@mail.ru
ORCID iD: 0000-0002-7662-4755
SPIN-code: 7810-3930

Cand. Sci. (Biology)

Россия, Saratov

Dzhalal F. Kazymov

Saratov State Medical University named after V.I. Razumovsky

Email: k.jalal@mail.ru
ORCID iD: 0009-0006-9835-0149
Россия, Saratov

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Copyright (c) 2024 Klimov V.N., Deryugina L.A., Krasnova E.I., Popyhova E.B., Kazymov D.F.

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